Unlocking limitless cell culture

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A natural cell growth technology that delivers superior performance at all scales

The only architecture that mimics how cells naturally grow

Precise and linear scaleup + automation ready formats

Enablement layer for AI-driven, automated workflows

XDemics’ natural cell growth technology unlocks performance at all scales

The only architecture that mimics how cells naturally grow

BIOLOGY PRESERVED
Direct O2 delivery

Direct, pericellular oxygen control across normoxic, physioxic, or hypoxic conditions, critical for maintaining stemness in T cell, MSC, HSC, and iPSC therapies.

Stress-free environment

No agitation, sparging, or shear. Native T cell clustering and paracrine signaling preserved at scale.  Higher quality, shear free viral vector production from 3D cell growth.

PROCESS INDUSTRIALIZED
Linear scale-up

Identical microenvironment at every scale, minimizing changes in biology as scale increases, lowering overall scaleup risk.

Automation ready

ANSI/SLAS footprint, liquid-handler compatible, and built as the enablement layer for AI-driven workflows and process design.

10-100x
Higher cell densities, with improved activity and quality vs. incumbent technologies
Dramatically lowers process complexity and costs
Expansify™ 24-Well Plate

The Expansify™ 24-Well Plate enables 10 to 100 times higher cell yields per well than conventional polystyrene cultureware. A single stackable plate can replace up to 24 T-75 flasks, reducing incubator footprint, consumable usage, labor, and process variability while delivering reproducible, high-density cell growth.

Research use only
Expansify™ Single-Well Plate

The Expansify™ Single-Well Plate supports hundreds of million cells per plate, delivering up to 10 to 100 times higher cell yields than conventional cultureware while providing a direct path from laboratory research to translational and production-scale workflows. A single stackable plate can replace up to eight T-225 flasks, reducing incubator footprint, labor, and process variability while delivering reproducible, high-density cell growth.

Research use only

Current cell growth technologies have a fundamental problem:


Poor oxygen transfer during cell growth, at all scales

Lack of max potential cell density, activity, and quality creates bottlenecks in end market applications:
CAR-T, TILs & cell therapies
Viral vectors
Regenerative medicine / stem cells
Adjacencies:
- Cells for biomedical R&D
- High throughput screening
  • Drug screening 3D culture / organoids
  • mAbs & biologics
  • Functional genomics
  • Proteomics
  • Metabolomics
  • Cell line development
Our solution
HDCR™ architecture mimics tissue capillary proximity and supports precise O₂ delivery.
Our geometry + material permeability enables natural, tissue-level cell density and quality at all scales
High Density Cell Respiration™ (HDCR™) technology is exclusively licensed from Caltech and City of Hope National Medical Center.

A smarter way to grow cells

How it works:

1

XDemics’ innovation combines a gas-permeable material with an exclusive geometric design to create ideal replicative niches for cells to grow.

2

This unique system ensures high-density cell growth while maintaining quality, scalability, and efficiency across research and industrial applications.

3

One proven production platform across the major modalities

Suspension cell, adherent cell or microcarrier-based expansion

T cells, viral vectors,  stem cells, proteins and organoids precisely cultured in any growth environment

Demonstration

Massive expansion of human cells

50,000 K-562 cells were seeded at Day 0, cells were expanded over 9 days in an Expansify™24-well plate. 9 million cells were harvested at >95% viability.

Day 1
Day 2
Day 3

Revolutionizing Cell Growth – Scaling Beyond Limits

Traditional cell culture methods are limited in scale and efficiency. With our breakthrough technology, we’ve expanded cell growth capabilities far beyond conventional limits. This graph illustrates the massive difference in viable cell yield over just 7 days in a single well of a 24-well plate.

50,000
250,000
8,000,000
Initial Seeded Cells (Day 0)
Conventional Plate Limit
Breakthrough Cell Growth (Day 7)
Graph scaled for readability—actual cell expansion is 32X over 7 days, far exceeding conventional limits.

True Scalability

Identical geometry and environment from a 96-well plate to 50L bioreactor

XDemics’ HDCR™ platform reduces biological risk of scaleup:
Identical, repeating geometry and environment allows for precise and linear scalability between small and large format Expansify™ cultureware (scale-up/scale-down)

Our Team

The people committed to advancing our innovative technology platform – from the laboratory bench to the production facility

Christopher Thanos, PhD
Chairman and CEO
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Colin Cook, PhD
CTO & Co-founder
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Adam Prime
Chief Operations Officer
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Nicholas Scianmarello, PhD
SVP, Manufacturing and Chief Engineer
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Forrest Roush, MBA
VP Business Development
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Yuman Fong, MD
Co-founder & Scientific Advisor
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YC Tai, PhD
Co-founder & Chair, Scientific Advisory Board
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Austin Santiago
Director Core Technologies & Field Application Specialist
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Armando Santiago
Lead Manufacturing and Logistics Technician
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Aishwarya Churi, MS
Scientist
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LingYi Qiu
Engineer II
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Joe Dobrzensky
Manufacturing Associate
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Bryan Cheung, CPA
Fractional Controller & Head of Finance
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Kristin Gordon
Head of Quality and Regulatory
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Tyliah Vu, MBA
Office and Finance Manager
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Nicole Bergman Fong, JD
Member, Board of Directors
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Katie Chudnovsky, JD
Observer, Board of Directors, GKCC
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Jennifer Shockro, PhD
Acting Board Observer, Caltech
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Robert Baffi, PhD
Scientific Advisor
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Stewart Craig, PhD
Scientific Advisor
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Contact us
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Location

Our biological testing laboratories are located within the prestigious Buck Institute at 8001 Redwood Blvd., Novato, CA 94945.

General inquiries:
info@xdemics.com
Technical support:
support@xdemics.com